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Apr 1, 2018 First-line therapy for symptomatic gallstones is cholecystectomy. Brown pigment stones, accounting for 5% to 10% of all gallstones, 6 are .Cholelithiasis answers are found in the 5-Minute Clinical Consult powered by Unbound Medicine. Available for iPhone, iPad, Android.[3,4] This disease is however, a worldwide medical problem, even though there are geographical variations in gallstone prevalence[5,6,7,8,9,10,11] Gallstones .A gallstone is a stone formed within the gallbladder out of bile components. The term Symptoms of these complications may include pain of more than five hours duration, fever, yellowish skin, vomiting, dark urine, and pale stools. Risk factors .Gallstones vary greatly in size. Some people may form one large stone, whereas others may have hundreds of tiny stones. Most commonly, gallstones are 5–10 .